Clinical Assessment of Efficacy of Cognitive Remediation in Patients with Schizophrenia Stabilized on Lurasidone
Jeffrey A. Lieberman, Gerard Bruder, Jürgen Kayser, Craig Tenke, Dan Alschuler, Jorge Alvarenga, Karen Abraham
As part of a multicenter trial to study to effects of cognitive remediation in patients stabilized on the antipsychotic lurasidone, a subset of patients with schizophrenia are participating in event-related potential (ERP) measures. ERPs and behavioral performance are being measured during an auditory recognition memory test. Patients are tested when they are stable near the end of 8th week of treatment with lurasidone and after about 4 to 6 months upon completion of cognitive remediation or a non-specific mental activity control condition. This will enable assessment of changes in auditory processing and recognition memory following cognitive remediation with Posit Science auditory training. The overall goal is to evaluate the utility of ERP as a biomarker of changes in cognitive function and as a predictor of improvement in cognitive function following cognitive remediation. All participants are also administered a Tone Screening Test (TST) to demonstrate the ability to discriminate tones of different frequency.