Tadeka Study No. ITI-214-102

Anissa Abi-Dargham, Gerard Bruder, Craig Tenke, Jürgen Kayser, Jorge Alvarenga, Karen Abraham, Dan Alschuler

EEG and brain event-related potentials (ERPs) are measured in 24 stable patients with schizophrenia before and after different dosages of ITI-214 or placebo treatment. Each subject will undergo EEG assessments without task (resting state) and followed by task-induced EEG measurements. During resting state measurements, the subject will not be asked to perform any tasks but will asked to open (O) or close (C) their eyes during four 2 minute blocks in a counterbalanced order (OCCO). During task induced measurements of ERPs, the subjects will perform several tasks. These include a mismatched negativity (MMN) task using tones of different frequency, an oddball task in which the subject presses a button to infrequent target tones that differ in frequency from standard tones, and a serial position test assessing working memory. During a familiarization session, the subject will receive practice on the above tasks and will be administered a Tone Screening Test (TST) to demonstrate the ability to discriminate tones of different frequency and to perform the ERP tasks.